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Gabapentin price in uk Turing trial results [19] A study from canada drug pharmacy 2003 found the average price of gabapentin gel increased 8% between 2005 to 2010, averaging £50 extra per capsule. [18]. A review of the evidence on gabapentin's therapeutic effect neuropathic pain found: "Gabapentin gel is not effective in the treatment of neuropathic pain in adults who do not have an established pain problem." [17]. In contrast, a Cochrane review revealed that duloxetine and nefazodone were more effective than gabapentin for chronic postoperative or pain after hip replacement surgery. [16]. In a meta-analysis of 14 studies oral gabapentin or and placebo, was found to have equivalent analgesic effects duloxetine, and was associated with lower risk of adverse events. [15]. A Cochrane review of 14 randomized controlled trials published up to 1 June 2008 concluded that for chronic postoperative pain after hip or knee replacement due to any cause, gabapentin or nefazodone was more likely to be as effective placebo, more tolerable, and less expensive in terms of use healthcare resources. [14]. In a large study, gabapentin increased duration of pain after hip or knee replacement surgery from 8 to 12 weeks compared with placebo, and was as effective duloxetine at reducing pain intensity after hip or knee replacement.[15]. [13]. In a randomized, double-blind, placebo-controlled study, duloxetine was more effective in reducing pain intensity when compared with gabapentin in patients knee osteoarthritis. [12]. A systematic review and meta-analysis of randomized controlled trials (RCTs) published up until 2009 showed that the effectiveness of oral gabapentin in patients with moderate to severe pain after hip or knee replacement was similar to that of pramipexole, with some differences between the two. [11]. A meta-analysis found that gabapentin was less effective than placebo on pain reduction and quality of life scores that no statistical differences were found between gabapentin and duloxetine by means of a fixed-effect analysis when the pooled data were analyzed. No differences between gabapentin and duloxetine were detected when pooled data analyzed and no were analysed for gabapentin or duloxetine in patients with pain on opioids or anti-emetics. [10]. A recent Cochrane review of randomized controlled trials confirmed that duloxetine's analgesic effects are more likely to be observed in the more severe, frequent pain states compared with the analgesic effects of gabapentin. [9]. In a randomized, double-blind, placebo-controlled study examining the effects of both oral duloxetine and gabapentin in patients with osteoarthritis and osteoarthrosis/osteomyelitis, duloxetine was found to be as effective gabapentin in reducing pain intensity, relief, quality of life, and patient-rated health status. http://www.ncbi.nlm.nih.gov/pubmed/21833808 http://www.ncbi.nlm.nih.gov/pubmed/22423444

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